A HISTOLOGICALLY COMPLETE RESPONSE TO IMMUNOTHERAPY USING PEMBROLIZUMAB IN A PATIENT WITH GIANT CELL CARCINOMA OF THE LUNG: AN ADDITIONAL REPORT AND LITERATURE REVIEW

We previously reported a case of giant cell carcinoma in the lung, Hair in which the use of antiprogrammed death 1 (PD-1) immunotherapy resulted in substantial tumor reduction.In the present study, we describe an additional clinical course.A 69-year-old woman was diagnosed with giant cell carcinoma of the lung in clinical stage IVB (T2bN0M1c, BRA).

The carotenoids are the most widely distributed secondary metabolites in plants and can be degraded by carotenoid cleavage dioxygenase (CCD) to form apocarotenoids including an important C13 compound beta-ionone.Volatile beta-ionone can confer the violet and woody fragrance to plant essential oils, flowers, fruits, and vegetables, which therefore h

Abstract Background Mast cell-derived prostaglandin D2 (PGD2), may contribute to eosinophilic inflammation and mucus production in allergic asthma.Chemoattractant receptor Accessories homologous molecule expressed on TH2 cells (CRTH2), a high affinity receptor for prostaglandin D2, mediates trafficking of TH2-cells, mast cells, and eosinophils to i

In a recent paper, we presented new evidence and provided new insights on the status of Cantabrian brown bear subpopulations, relevant for this species conservation.Namely, we revealed the likely phylogeographic relation between eastern Cantabrian subpopulation and the historical Pyrenean population.We have also detected an asymmetric flow of allel